Why do Vitamin Forms matter?
With the number of different supplements out there (picture the
row of vitamin C supplements alone!), it should interest you to know that vitamins come in forms that have
important differences, and these forms can often have different functions as well as different rates of absorption.
Taking a supplement that is not in a bio-available form can cause more strain on our bodies and end up doing more
harm than good. That is why it is so important to check the forms of the various vitamins in your supplements.
The form of a vitamin does matter.
This is true for ALL vitamins. However, it is especially important with fat
soluble vitamins, because of their higher risk of toxicity - which is why I will be focusing on the different forms
of fat soluble vitamins (D, E, K, A) in this blog. For more on fat soluble vitamins, you can read my previous blog
post on the subject here (link to previous blog).
Vitamin A: Natural vs Synthetic
Many people worry about vitamin A because of its toxicity. However, it is the
retinoic acid form of vitamin A that is problematic.
Vitamin A is actually a family of substances called retinoids that include
retinol, retinal and retinoic acid. These are called preformed vitamin A because they are in a form that the body
readily uses. Retinol is the most usable of the three and can be converted to both retinal and retinoic acid in the
Plant sources contain ‘provitamin A’ called carotenoids, which can be
enzymatically converted to retinol in your body. Carotenoids are the yellow-red pigments that give carrots,
butternut squash and cantaloupe their vibrant, deep orange colour.
There are over 600 different carotenoids, but only 3, beta carotene, beta
cryptoxanthin and alpha carotene can be converted to vitamin A. Beta
carotene is known to have antioxidant properties, and it can help
to neutralize free radicals that damage tissues, including those in the eye. This is the form that Xtend-Life
uses in all our supplements.
Synthetic vitamin A is often listen as vitamin A palmitate, retinyl palmitate or
retinol palmitate. If you see this on your supplement label… run! Synthetic vitamin A is an isolate and where
isolates are concerned, you often see problems with digestion, absorption, uptake and assimilation. Some research
shows that long-term consumption may result in dry skin, eyes and lips, hair loss, sleepiness or fatigue, liver
damage and bone demineralization.
Vitamin K1, K2 or K3?
Vitamin K is a great vitamin that provides a number of different health benefits.
These benefits vary depending on the form of vitamin K you ingest.
- Vitamin K1 (phylloquinone)
Found naturally in plants (especially green vegetables), K1 goes directly to your
liver and helps you maintain healthy blood clotting.
Made by the bacteria that line your gastrointestinal tract (and from fermented
foods), the biological role of vitamin K2 is to help move calcium into the proper areas in your body, such as your
bones and teeth. This is the form I recommend for supplementation, as it is natural and non-toxic, even at 500
times the recommended daily allowance (RDA). Increasing your K2 by consuming more fermented foods is the most
desirable way to increase your levels. The food that has the highest concentration of natural K2 is natto, which is
a form of fermented soybeans.
This is a synthetic form that we cannot recommend. It is important to note that
toxicity has occurred in infants injected with synthetic vitamin K3.
Vitamin D2 or D3
Vitamin D is known to have a large number of health benefits, including its
widely-known support for bone density. Supplemental vitamin D comes in two forms - ergocalciferol (vitamin D2) and
cholecalciferol (vitamin D3).
Both forms of vitamin D were once regarded as equivalent and interchangeable.
However, we know a lot more about vitamin D today, and studies are showing compelling evidence that vitamin
D3 is the best form to take in oral
supplementation. According to the latest research, vitamin D3 is more potent in raising and maintaining vitamin D
concentrations than vitamin D2. Vitamin D3 is also the same type of D vitamin created in your body when you expose
your skin to sunlight.
Regardless of which form of a vitamin you use, your body
must convert it into a more active form, and vitamin
D3 is converted 500
percent faster than vitamin D2. Vitamin D2 also has a shorter
shelf life, and its metabolites bind poorly with proteins, further hampering its effectiveness.
Unfortunately, vitamin D2—which is a synthetic version made by irradiating fungus
and plant matter—is the form of vitamin D most often prescribed by doctors in the U.S. Hopefully this will change
sooner rather than later.
Vitamin E, Tocopherols and Tocotrienols
E is a fat-soluble vitamin with antioxidant properties. Vitamin E
exists in eight different forms: alpha-, beta-, gamma-, and delta-tocopherol; and alpha-, beta-, gamma-, and
Alpha-tocopherol is the most active form in humans because it is the preferred form of vitamin E transported and
used by the liver.
Vitamin E supplements are available in natural or man-made forms. Synthetic
vitamin E does not come from a natural food source and is generally derived from petroleum products. Due to its
chemical structure, it is much less potent than natural vitamin E. It is also significantly less bioavailable, with
decreased overall absorption and utilization. Synthetic forms are labelled “dl” (for example, dl-alpha-tocopherol).
Natural forms are usually labelled with the letter “d” (for example, d-gamma tocopherol). The best type of vitamin
E should be a combination of tocotrienols and tocopherols – as they work in synergy to provide optimum
Know your vitamin form!
This is just a brief introduction to the important differences between different
forms of vitamins. I would strongly encourage you as a reader to do your research prior to purchasing a supplement.
Any reputable supplement company should have the details of their vitamin forms available on their website or the
Supplement Facts panel on the product label
Is more really a good thing?